バイオロジックス開発のための細胞ベースバイオアッセイおよびイムノアッセイ

Functional Cell-based Bioassays and Immunoassays for Biologics Drug Development Precise. Accurate. Low variability. Functional Cell-based Bioassays and Immunoassays for Biologics Drug Development Precise. Accurate. Low variability. PROMEGA CORPORATION • 2800 WOODS HOLLOW ROAD • MADISON, WI 53711 -5399 USA • TELEPHONE 608-274-4330 www.promega.com • © 2022 PROMEGA CORPORATION • ALL RIGHTS RESERVED • PRICES AND SPECIFICATIONS SUBJECT TO CHANGE WITHOUT PRIOR NOTICE • PRINTED IN USA 01/22 • 65014199 • #GE921 Product Category Page Human ADCC Reporter Bioassays 2 Mouse ADCC Bioassays 2 Human PBMC ADCC Bioassays 3 Human ADCP Bioassays 3 Human Fc Receptor Binding Immunoassays 3 Other Human Fc Receptor Bioassays 4 Target Cell Killing–HiBiT Target Cells 4 Immune Checkpoint Co-Inhibitory Bioassays 5 Immune Checkpoint Co-Stimulatory Bioassays 7 Accessory Cell Kits for Immune Checkpoint Co-Stimulatory Bioassays 8 Immune Checkpoint Combination Bioassays 8 T Cell Activation Bioassays 9 T Cell Dependent Cellular Cytotoxicity (TDCC) Bioassays 9 Innate Immune Receptor Bioassays 10 PsVLP Assays 10 Cytokine and Growth Factor Bioassays 11 Other Reporter Cell Lines for Biologics Drug Development 12 PROMEGA CORPORATION • 2800 WOODS HOLLOW ROAD • MADISON, WI 53711 -5399 USA • TELEPHONE 608-274-4330 www.promega.com • © 2022 PROMEGA CORPORATION • ALL RIGHTS RESERVED • PRICES AND SPECIFICATIONS SUBJECT TO CHANGE WITHOUT PRIOR NOTICE • PRINTED IN USA 01/22 • 65014199 • #GE921 Human ADCC Reporter Bioassays Mouse ADCC Bioassays Bioassay Cell Components Part # Mouse FcRIV ADCC Reporter Bioassay Complete Kit1 Mouse FcRIV Effector Cells M1201 Core Kit2. M1211 Core Kit 5X M1215 Propagation Model4 M1212 Mouse FcRIII ADCC Reporter Bioassay Core Kit2. Mouse FcRIII Effector Cells CS1779B08 Propagation Model4 CS1779B06 Bioassay Cell Components Part # ADCC Reporter Bioassays Complete Kit (WIL2-S)1 FcRIIIa-V158 Effector Cells Target Cells: WIL2-S or Raji cells G7014 Complete Kit (Raji) G7015 Core Kit2. G7010 Core Kit 5X G7018 Target Kit (WIL2-S)3 G7013 Target Kit (Raji) G7016 Propagation Model4 G7102 CD38 Knock-Out Core Kit FcRIIIa-V158 Effector Cells, CD38-KO CS313304 CD38 Knock-Out Core Kit 5X CS313306 CD38 Knock-Out, Propagation Model CS313302 Control Ab, Anti-CD20 N/A GA1130 ADCC Reporter Bioassay, F Variant5 Core Kit2. FcRIIIa-F158 Effector Cells G9790 Core Kit 5X G9798 Propagation Model4 G9302 Target Cells for ADCC Reporter Bioassays6 Membrane TNFα Target Cells Membrane TNFα Target Cells J3331 Membrane TNFα Target Cells 5X J3335 Membrane TNFα Target Cells, Propagation Model J3322 Membrane VEGF Target Cells Membrane VEGF Target Cells J3351 Membrane VEGF Target Cells 5X J3355 Membrane VEGF Target Cells, Propagation Model J3342 Membrane RANKL Target Cells Membrane RANKL Target Cells J3381 Membrane RANKL Target Cells 5X J3385 Membrane RANKL Target Cells, Propagation Model J3362 PD-1 Target Cells7 PD-1 Cells Please Enquire CTLA-4 Target Cells7 CTLA-4 Cells Please Enquire SARS-CoV-2 CHO-K1 Cells SARS-CoV-2 CHO-K1 Cells CS3195A05 SARS-CoV-2 CHO-K1 Cells 5X CS3195A06 SARS-CoV-2 CHO-K1 Cells, Propagation Model CS3195A08 Return to Table of Contents PROMEGA CORPORATION • 2800 WOODS HOLLOW ROAD • MADISON, WI 53711 -5399 USA • TELEPHONE 608-274-4330 www.promega.com • © 2022 PROMEGA CORPORATION • ALL RIGHTS RESERVED • PRICES AND SPECIFICATIONS SUBJECT TO CHANGE WITHOUT PRIOR NOTICE • PRINTED IN USA 01/22 • 65014199 • #GE921 Human PBMC ADCC Bioassays Bioassay Cell Components Part # Human PBMC, ADCC-Qualified Human PBMC, ADCC-Qualified Human PBMC, ADCC Qualified CS3055A01 Human PBMC, ADCC Qualified 5X Please Enquire Human PBMC ADCC Bioassay Kits PBMC ADCC Bioassay Kit (Raji) Human PBMC, ADCC Qualified Raji Cells (HiBiT)24 CS3055A14 PBMC ADCC Bioassay Kit 5X (Raji) CS3055A17 PBMC ADCC Bioassay Kit (Ramos) Human PBMC, ADCC Qualified Ramos Cells (HiBiT)24 CS3055A20 PBMC ADCC Bioassay Kit 5X (Ramos) CS3055A22 PBMC ADCC Bioassay Kit (SK-BR-3) Human PBMC, ADCC Qualified SK-BR-3 Cells (HiBiT)24 CS3055A36 PBMC ADCC Bioassay Kit 5X (SK-BR-3) CS3055A38 PBMC ADCC Bioassay Kit (A549) Human PBMC, ADCC Qualified A549 Cells (HiBiT)24 CS3055A24 PBMC ADCC Bioassay Kit 5X (A549) CS3055A26 PBMC ADCC Bioassay Kit (H929) Human PBMC, ADCC Qualified H929 Cells (HiBiT)24 CS3055A28 PBMC ADCC Bioassay Kit 5X (H929) CS3055A30 Human ADCP Bioassays Bioassay Cell Components Part # FcRIIa-H ADCP Reporter Bioassay Complete Kit1 FcRIIa-H131 Effector Cells G9901 Core Kit2. G9991 Core Kit 5X G9995 Propagation Model4 G9871 FcRIIa-R ADCP Reporter Bioassay Core Kit2. FcRIIa-R131 Effector Cells CS1781B08 Propagation Model4 CS1781B06 FcRI ADCP Reporter Bioassay Core Kit2. FcRI Effector Cells GA1341 Core Kit 5X GA1345 Propagation Model4 GA1332 Cell Bank25 GA1330 ADCP Reporter Bioassay (THP-1) ADCP Reporter Bioassay (THP-1) ADCP Bioassay Effector Cells (THP-1) CS314904 ADCP Reporter Bioassay (THP-1) 5X CS314906 ADCP Reporter Bioassay (THP-1), Propagation Model CS314902 Human Fc Receptor Binding Immunoassays Product # Assays Part # Lumit™ FcR Binding Immunoassays FcRn Binding Immunoassay 100 assays W1151 FcRn Binding Immunoassay 10X 1000 assays W1152 FcγRI Binding Immunoassay 100 assays CS3041A01 FcγRIIA (H131) Binding Immunoassay 100 assays CS3041A02 FcγRIIA (R131) Binding Immunoassay 100 assays CS3041A03 FcγRIIIA (V158) Binding Immunoassay 100 assays CS3041A04 FcγRIIIA (F158) Binding Immunoassay 100 assays CS3041A05 Return to Table of Contents PROMEGA CORPORATION • 2800 WOODS HOLLOW ROAD • MADISON, WI 53711 -5399 USA • TELEPHONE 608-274-4330 www.promega.com • © 2022 PROMEGA CORPORATION • ALL RIGHTS RESERVED • PRICES AND SPECIFICATIONS SUBJECT TO CHANGE WITHOUT PRIOR NOTICE • PRINTED IN USA 01/22 • 65014199 • #GE921 Other Human Fc Receptor Bioassays Bioassay Cell Components Part # FcRIIb Reporter Bioassay Core Kit2 FcRIIb/IIa Effector Cells8 CS1781E02 Core Kit 5X CS1781E04 Propagation Model4 CS1781E07 FcR Effector Bioassay Bundles Human FcR Bioassay 5-Pack 1 each: FcRIIIa-V158, FcRIIIa-F158, FcRIIa-H131, FcRIIa-R131, FcRI Effector Cells CS1781D02 Target Cell Killing – HiBiT Target Cells Bioassay Part # HiBiT Target Cells Raji Cells (HiBiT) CS3055A02 Raji Cells (HiBiT), Propagation Model CS3055A04 Raji CD19-KO Cells (HiBiT) (*parental cells – CS3000A45) CS3000A47 Raji CD19-KO Cells (HiBiT), Propagation Model (*parental cells – CS3000A18) CS3000A20 Raji CD20-KO Cells (HiBiT) (*parental cells – CS3000A45) CS3000A69 Raji CD20-KO Cells (HiBiT), Propagation Model (*parental cells – CS3000A18) CS3000A56 Raji CD-19, CD20-KO Cells (HiBiT), Propagation Model (*parental cells – CS3000A18) CS3000A57 Ramos Cells (HiBiT) CS3055A05 Ramos Cells (HiBiT), Propagation Model CS3055A07 Ramos CD19-KO Cells (HiBiT), Propagation Model (*parental cells – CS3000A22) CS3000A24 A549 Cells (HiBiT) CS3055A08 A549 Cells (HiBiT), Propagation Model CS3055A10 Claudin 18.2 CHO-K1 (HiBiT), Propagation Model CS347203 SK-BR-3 Cells (HiBiT) CS3055A35 SK-BR-3 Cells (HiBiT), Propagation Model CS3055A33 H929 Cells (HiBiT) CS3055A11 H929 Cells (HiBiT), Propagation Model CS3055A13 U937 Cells (HiBiT), Propagation Model CS3000A08 OVCAR3 Cells (HiBiT) CS3000A40 OVCAR3 Cells (HiBiT), Propagation Model CS3000A29 SKOV3 Cells (HiBiT) CS3000A43 SKOV3 Cells (HiBiT), Propagation Model CS3000A33 T2 Cells (HiBiT), Propagation Model CS3000A35 K562 Cells (HiBiT) CS3000A52 K562 Cells (HiBiT), Propagation Model CS3000A50 GPC3 K562 Cells (HiBiT) CS3000A66 GPC3 K562 Cells (HiBiT), Propagation Model CS3000A64 CD19 K562 Cells (HiBiT), Propagation Model CS3000A25 BCMA K562 Cells (HiBiT), Propagation Model CS3000A16 Membrane TNFa CHO-K1 Cells (HiBiT) CS3055A46 Membrane TNFa CHO-K1 Cells (HiBiT), Propagation Model CS3055A44 SARS-CoV2-S CHO-K1 Cells (HiBiT) CS3195A01 SARS-CoV2-S CHO-K1 Cells (HiBiT), Propagation Model CS3195A04 Vectors HiBiT Vector (CAG promoter, BlastR) CS1956B17 Return to Table of Contents PROMEGA CORPORATION • 2800 WOODS HOLLOW ROAD • MADISON, WI 53711 -5399 USA • TELEPHONE 608-274-4330 www.promega.com • © 2022 PROMEGA CORPORATION • ALL RIGHTS RESERVED • PRICES AND SPECIFICATIONS SUBJECT TO CHANGE WITHOUT PRIOR NOTICE • PRINTED IN USA 01/22 • 65014199 • #GE921 Immune Checkpoint Co-Inhibitory Bioassays Bioassay Cell Components Part # PD-1/PD-L1 Blockade Bioassay PD-1/PD-L1 Blockade Bioassay9 PD-1 Effector Cells PD-L1 aAPC/CHO-K1 Cells10 J1250 PD-1/PD-L1 Blockade Bioassay 5X J1255 PD-1/PD-L1 Blockade Bioassay, Propagation Model4 J1252 PD-L1 Negative Cells PD-L1 Negative aAPC/CHO-K1 Cells J1191 PD-L1 Negative Cells 5X J1195 Control Ab, Anti-PD-1 N/A J1201 Mouse PD-1/PD-L1 Blockade Bioassay Mouse PD-1/PD-L1 Blockade Bioassay Kit9 Mouse PD-1 Effector Cells Mouse PD-L1 aAPC/CHO-K1 Cells10 CS303201 Mouse PD-1/PD-L1 Blockade Bioassay Kit 5X CS303205 Mouse PD-1/PD-L1 Blockade Bioassay, Propagation Model4 CS303209 PD-1/PD-L2 Blockade Bioassay PD-1/PD-L2 Blockade Bioassay Kit9 PD-1 Effector Cells PD-L2 aAPC/CHO-K1 Cells10 CS187131 PD-1/PD-L2 Blockade Bioassay Kit 5X CS187135 PD-1/PD-L2 Blockade Bioassay, Propagation Model4 CS187142 PD-L2 aAPC/CHO-K1 Cells, Propagation Model4 PD-L2 aAPC/CHO-K1 Cells10 CS187141 CTLA-4 Blockade Bioassay CTLA-4 Blockade Bioassay9 CTLA-4 Effector Cells aAPC/Raji Cells10 JA3001 CTLA-4 Blockade Bioassay 5X JA3005 CTLA-4 Blockade Bioassay, Propagation Model4 JA1400 Control Ab, Anti-CTLA-4 N/A JA1020 TIGIT/CD155 Blockade Bioassay23 TIGIT/CD155 Blockade Bioassay9 TIGIT Effector Cells CD155 aAPC/CHO-K1 Cells10 J2201 TIGIT/CD155 Blockade Bioassay 5X J2205 TIGIT/CD155 Blockade Bioassay, Propagation Model4 J2092 TIGIT Negative Cells TIGIT Negative Effector Cells J1921 CD112R/CD112 Blockade Bioassay CD112R/CD112 Blockade Bioassay Kit9 CD112R Effector Cells CD112 aAPC/CHO-K1 Cells10 CS314006 CD112R/CD112 Blockade Bioassay Kit 5X CS314008 CD112R/CD112 Blockade Bioassay, Propagation Model4 CS314001 Control Ab, Anti-TIGIT N/A J2051 TIGIT/CD112 Blockade Bioassay TIGIT/CD112 Blockade Bioassay Kit9 TIGIT Effector Cells CD112 aAPC/CHO-K1 Cells CS198826 TIGIT/CD112 Blockade Bioassay Kit 5X CS198829 TIGIT/CD112 Blockade Bioassay, Propagation Model4 Please Enquire CD226/CD155 Blockade Bioassay CD226/CD155 Blockade Bioassay Kit9 TCR/CD3 Effector Cells (IL-2) CD155 aAPC/CHO-K1 Cells10 CS1978F01 CD226/CD155 Blockade Bioassay, Propagation Model4 Please Enquire Return to Table of Contents PROMEGA CORPORATION • 2800 WOODS HOLLOW ROAD • MADISON, WI 53711 -5399 USA • TELEPHONE 608-274-4330 www.promega.com • © 2022 PROMEGA CORPORATION • ALL RIGHTS RESERVED • PRICES AND SPECIFICATIONS SUBJECT TO CHANGE WITHOUT PRIOR NOTICE • PRINTED IN USA 01/22 • 65014199 • #GE921 Immune Checkpoint Co-Inhibitory Bioassays (cont.) Bioassay Cell Components Part # LAG-3/MHCII Blockade Bioassay LAG-3/MHCII Blockade Bioassay11 LAG-3 Effector Cells MHCII APC Cells JA1111 LAG-3/MHCII Blockade Bioassay 5X JA1115 LAG-3/MHCII Blockade Bioassay, Propagation Model4 JA1112 TCR Activating Antigen N/A K1201 Control Ab, Anti-LAG-3 K1150 TIM-3 Bioassay TIM-3 Bioassay Kit9 TIM-3 Effector Cells TIM-3 Target Cells JA2211 TIM-3 Bioassay Kit 5X JA2215 TIM-3 Bioassay, Propagation Model4 JA2222 Control Ab, Anti-TIM-3 N/A K1210 ICOS Blockade Bioassay13 ICOS Blockade Bioassay Kit9 ICOS Effector Cells ICOSL aAPC/CHO-K1 Cells10 JA6001 ICOS Blockade Bioassay Kit 5X JA6005 ICOS Blockade Bioassay, Propagation Model4 JA6072 Control Ab, Anti-ICOS N/A K1241 CD28 Blockade Bioassay5 CD28 Blockade Bioassay Kit9 CD28 Effector Cells aAPC/Raji Cells10 JA6101 CD28 Blockade Bioassay Kit 5X JA6105 CD28 Blockade Bioassay, Propagation Model4 JA7072 Control Ab, Anti-CD28 N/A K1231 BTLA/HVEM Blockade Bioassay BTLA/HVEM Blockade Bioassay Kit9 BTLA Effector Cells HVEM aAPC/CHO-K1 Cells10 CS1978E04 BTLA/HVEM Blockade Bioassay Kit 5X CS1978E08 BTLA/HVEM Blockade Bioassay, Propagation Model4 CS1978E01 SIRPα/CD47 Blockade Bioassays12 SIRPα/CD47 Blockade Bioassay, Fc-Dependent9 SIRPα Effector Cells CD47 CHO-K1 Target Cells CS316013 SIRPα/CD47 Blockade Bioassay, Fc-Dependent 5X CS316015 SIRPα/CD47 Blockade Bioassay, Fc-Dependent, Propagation Model4 CS316005 SIRPα/CD47 Blockade Bioassay SIRPα Effector Cells CD47/FcγR-A CHO-K1 Target Cells CS316009 SIRPα/CD47 Blockade Bioassay 5X CS316011 SIRPα/CD47 Blockade Bioassay, Propagation Model4 CS316004 ILT4/HLA-G Blockade Bioassay9 *ILT4 also known as LILRB2 ILT4/HLA-G Blockade Bioassay ILT4 Effector Cells HLA-G aAPC/CHO-K1 Cells CS331106 ILT4/HLA-G Blockade Bioassay 5x CS331108 ILT4/HLA-G Blockade Bioassay, Propagation Model CS331103 Return to Table of Contents PROMEGA CORPORATION • 2800 WOODS HOLLOW ROAD • MADISON, WI 53711 -5399 USA • TELEPHONE 608-274-4330 www.promega.com • © 2022 PROMEGA CORPORATION • ALL RIGHTS RESERVED • PRICES AND SPECIFICATIONS SUBJECT TO CHANGE WITHOUT PRIOR NOTICE • PRINTED IN USA 01/22 • 65014199 • #GE921 Immune Checkpoint Co-Stimulatory Bioassays Bioassay Cell Components Part # 4-1BB Bioassay 4-1BB Bioassay9 4-1BB Effector Cells JA2351 4-1BB Bioassay 5X JA2355 4-1BB Bioassay, Propagation Model4 J2332 Control Ab, Anti-4-1BB N/A K1161 CD40 Bioassay CD40 Bioassay Kit9 CD40 Effector Cells JA2151 CD40 Bioassay Kit 5X JA2155 CD40 Bioassay, Propagation Model4 J2132 Control Ab, Anti-CD40 N/A K1181 OX40 Bioassay OX40 Bioassay Kit9 OX40 Effector Cells JA2191 OX40 Bioassay Kit 5X JA2195 OX40 Bioassay, Propagation Model4 J2172 Control Ab, Anti-OX40 N/A K1191 Mouse OX40 Bioassay, Propagation Model4 Mouse OX40 Effector Cells CS326802 GITR Bioassay GITR Bioassay Kit9 GITR Effector Cells JA2291 GITR Bioassay Kit 5X JA2295 GITR Bioassay, Propagation Model4 J2272 Control Ab, Anti-GITR N/A K1171 ICOS Bioassay14 ICOS Bioassay, Core Kit9 ICOS Effector Cells JA6801 ICOS Bioassay, Core Kit 5X JA6805 ICOS Bioassay, Propagation Model4 ICOS Effector Cells FcγRIIb aAPC/CHO-K1 Cells JA3072 Control Ab, Anti-ICOS N/A K1241 CD28 Bioassay14 CD28 Bioassay, Core Kit9 CD28 Effector Cells JA6701 CD28 Bioassay, Core Kit 5X JA6705 CD28 Bioassay, Propagation Model4 CD28 Effector Cells FcγRIIb aAPC/CHO-K1 Cells JA1072 Control Ab, Anti-CD28 N/A K1231 HVEM/LIGHT Bioassay HVEM/LIGHT Bioassay Kit9 HVEM Effector Cells CS1979A30 HVEM/LIGHT Bioassay Kit 5X CS1979A32 HVEM/LIGHT Bioassay, Propagation Model4 CS1979A16 LIGHT CHO-K1 Cells, Propagation Model LIGHT CHO-K1 Cells Please Enquire CD27 Bioassay CD27 Bioassay Kit9 CD27 Effector Cells CS1979A23 CD27 Bioassay Kit 5X CS1979A25 CD27 Bioassay, Propagation Model4 CS1979A15 CD70 Cells15 CD70 CHO-K1 Cells CS1979A19 DR3 Bioassay DR3 Bioassay Kit9 DR3 Effector Cells CS1979E03 DR3 Bioassay Kit 5X CS1979E06 DR3 Bioassay, Propagation Model4 CS1979E02 Return to Table of Contents PROMEGA CORPORATION • 2800 WOODS HOLLOW ROAD • MADISON, WI 53711 -5399 USA • TELEPHONE 608-274-4330 www.promega.com • © 2022 PROMEGA CORPORATION • ALL RIGHTS RESERVED • PRICES AND SPECIFICATIONS SUBJECT TO CHANGE WITHOUT PRIOR NOTICE • PRINTED IN USA 01/22 • 65014199 • #GE921 Accessory Cell Kits for Immune Checkpoint Co-Stimulatory Bioassays FcRIIb+ CHO-K1 Cells for GITR, 4-1BB, OX40, and CD40 Bioassays Cell Components Part # FcRIIb CHO-K1 Cells16 FcRIIb CHO-K1 Cells JA2251 FcRIIb CHO-K1 Cells 5X JA2255 FcRIIb CHO-K1 Cells, Propagation Model4 J2232 FcRIIb+ aAPC/CHO-K1 Cells for ICOS & CD28 Bioassays Cell Components Part # FcRIIb aAPC/CHO-K1 Cells17 FcRIIb aAPC/CHO-K1 Cells10 JA9331 FcRIIb aAPC/CHO-K1 Cells 5X JA9335 FcRIIb aAPC/CHO-K1 Cells, Propagation Model J3252 aAPC/CHO-K1 Cells for ICOS & CD28 Bioassays Cell Components Part # aAPC/CHO-K1 Cells17 aAPC/CHO-K1 Cells10 JA9441 aAPC/CHO-K1 Cells 5X JA9445 aAPC/CHO-K1 Cells Propagation Model J3312 Immune Checkpoint Combination Bioassays Bioassay Cell Components Part # PD-1+CTLA-4 Combination Bioassay PD-1+CTLA-4 Combination Bioassay9 PD-1+CTLA-4 Effector Cells PD-L1 aAPC/Raji Cells10 CS1978D04 PD-1+CTLA-4 Combination Bioassay 5X CS1978D08 PD-1+CTLA-4 Combination Bioassay, Propagation Model4 CS1978D03 PD-1+TIGIT Combination Bioassay PD-1+TIGIT Combination Bioassay9 PD-1+TIGIT Effector Cells PD-L1+CD155 aAPC/CHO-K1 Cells10 J2211 PD-1+TIGIT Combination Bioassay 5X J2215 PD-1+TIGIT Combination Bioassay, Propagation Model4 J2102 TIGIT Negative Cells TIGIT Negative Effector Cells J1921 PD-1+LAG-3 Combination Bioassay PD-1+LAG-3 Combination Bioassay Kit9 PD-1+LAG-3 Effector Cells PD-L1+MHCII APC Cells CS1978B11 PD-1+LAG-3 Combination Bioassay Kit 5X CS1978B15 PD-1+LAG-3 Combination Bioassay, Propagation Model4 CS1978B07 PD-1+4-1BB Combination Bioassay PD-1+4-1BB Combination Bioassay Kit9 PD-1+4-1BB Effector Cells PD-L1 aAPC/CHO-K1 Cells10 CS1978I05 PD-1+4-1BB Combination Bioassay Kit 5X CS1978I07 PD-1+4-1BB Combination Bioassay, Propagation Model4 CS1978I03 PD-1+OX40 Combination Bioassay PD-1+OX40 Combination Bioassay Kit9 PD-1+OX40 Effector Cells PD-L1 aAPC/CHO-K1 Cells10 CS307804 PD-1+OX40 Combination Bioassay Kit, 5X CS307805 PD-1+OX40 Combination Bioassay Kit, Propagation Model4 Please Enquire Return to Table of Contents PROMEGA CORPORATION • 2800 WOODS HOLLOW ROAD • MADISON, WI 53711 -5399 USA • TELEPHONE 608-274-4330 www.promega.com • © 2022 PROMEGA CORPORATION • ALL RIGHTS RESERVED • PRICES AND SPECIFICATIONS SUBJECT TO CHANGE WITHOUT PRIOR NOTICE • PRINTED IN USA 01/22 • 65014199 • #GE921 T Cell Activation Bioassays Bioassay Cell Components Part # T Cell Activation Bioassay (IL-2)18 T Cell Activation Bioassay (IL-2)9 TCR/CD3 Effector Cells (IL-2) J1651 T Cell Activation Bioassay (IL-2) 5X J1655 T Cell Activation Bioassay (IL-2), Propagation Model4 J1631 T Cell Activation Bioassay (IL-2), Propagation Model4 – Nluc Version TCR/CD3 Effector Cells (IL-2) – Nluc Version CS187005 T Cell Activation Bioassay (NFAT)18 T Cell Activation Bioassay (NFAT) 9 TCR/CD3 Effector Cells (NFAT) J1621 T Cell Activation Bioassay (NFAT) 5X J1625 T Cell Activation Bioassay (NFAT), Propagation Model4 J1601 T Cell Activation Bioassay (NFkB)18 T Cell Activation Bioassay (NFkB), Propagation Model TCR/CD3 Effector Cells (NFkB) CS1979A01 T Cell Activation Bioassays (TCRαβ-KO) T Cell Activation Bioassay (TCRαβ-KO, CD4+), Propagation Model4 TCRαβ-KO (CD4+) Cells GA1172 T Cell Activation Bioassay (TCRαβ-KO, CD4+), Cell Bank25 GA1210 T Cell Activation Bioassay (TCRαβ-KO, CD8+), Propagation Model4 TCRαβ-KO (CD8+) Cells GA1162 T Cell Activation Bioassay (TCRαβ-KO, CD8+), Cell Bank25 GA1220 T Cell Activation Bioassay (TCRαβ-KO, CD4+, CD8+), Propagation Model4 TCRαβ-KO (CD4+CD8+) Cells GA1182 T Cell Activation Bioassay (TCRαβ-KO, CD4+, CD8+), Cell Bank25 GA1230 TCRαβ-KO, CD4+CD8+) Cells19 Please Enquire TCRαβ-KO (CD4+CD8+) Cells 5X Please Enquire TCR Transfection Positive Control Kit23 MHCII APC Cells CS310109 DMF5 TCRαβ-KO (CD8+), Propagation Model20 DMF5 TCRαβ-KO Cells (CD8+) CS310108 T Cell Dependent Cellular Cytotoxicity (TDCC) Bioassays Bioassay Cell Components Part # Human T Cell (CD8+) TDCC Bioassay Kits Human T Cell (CD8+) TDCC Bioassay Kit (Ramos) Human T Cell (CD8+), TDCC-Qualified Ramos Cells (HiBiT)24 CS3055B02 Human T Cell (CD8+) TDCC Bioassay Kit 5X (Ramos) CS3055B05 Human T Cell (CD8+) TDCC Bioassay Kit (H929) Human T Cell (CD8+), TDCC-Qualified H929 Cells (HiBiT)24 CS3055B08 Human T Cell (CD8+) TDCC Bioassay Kit 5X (H929) CS3055B09 Human T Cell (CD8+) TDCC Bioassay Kit (SK-BR-3) Human T Cell (CD8+), TDCC-Qualified H929 Cells (HiBiT)24 CS3055B10 Human T Cell (CD8+) TDCC Bioassay Kit 5X (SK-BR-3) CS3055B11 Human T Cell (CD8+), TDCC Qualified Human T Cell (CD8+), TDCC Qualified Human T Cell (CD8+), TDCC-Qualified CS3055B03 Human T Cell (CD8+), TDCC Qualified 5X CS3055B06 Return to Table of Contents PROMEGA CORPORATION • 2800 WOODS HOLLOW ROAD • MADISON, WI 53711 -5399 USA • TELEPHONE 608-274-4330 www.promega.com • © 2022 PROMEGA CORPORATION • ALL RIGHTS RESERVED • PRICES AND SPECIFICATIONS SUBJECT TO CHANGE WITHOUT PRIOR NOTICE • PRINTED IN USA 01/22 • 65014199 • #GE921 Innate Immune Receptor Bioassays Bioassay Cell Components Part # TLR Bioassay21 TLR Bioassay Kit9 TLR Bioassay Cells CS317904 TLR Bioassay Kit 5X CS317906 TLR Bioassay, Propagation Model4 CS317902 ILT4/HLA-G Blockade Bioassay9 *ILT4 also known as LILRB2 ILT4/HLA-G Blockade Bioassay ILT4 Effector Cells HLA-G aAPC/CHO-K1 Cells CS331106 ILT4/HLA-G Blockade Bioassay 5x CS331108 ILT4/HLA-G Blockade Bioassay, Propagation Model CS331103 PsVLP Assays Bioassay Cell Components Part # SARS-CoV-2 HiBiT-PsVLP Assay, Complete Kit SARS-CoV-2 S(G614) HiBiT-PsVLPs SARS-CoV-2 HEK293T(LgBiT) Target Cells CS329524 SARS-CoV-2 HiBiT-PsVLP Assay, Complete Kit 5X SARS-CoV-2 S(G614) HiBiT-PsVLPs SARS-CoV-2 HEK293T(LgBiT) Target Cells CS329528 SARS-CoV-2 HiBiT-PsVLP Assay, Target Kit SARS-CoV-2 HEK293T(LgBiT) Target Cells CS329531 SARS-CoV-2 HiBiT-PsVLP Assay, Target Kit 5X SARS-CoV-2 HEK293T(LgBiT) Target Cells CS329532 SARS-CoV-2 S(G614) HiBiT-PsVLPs CS329501 SARS-CoV-2 S(G614) HiBiT-PsVLPs 5X CS329502 SARS-CoV-2 S(Delta) HiBiT-PsVLPs CS329509 SARS-CoV-2 S(Delta) HiBIT-PsVLPs 5X CS329510 SARS-CoV-2 S(Omicron) HiBiT-PsVLPs CS329533 SARS-CoV-2 S(Omicron) HiBiT-PsVLPs 5X CS329534 SARS-CoV-2 S(Alpha) HiBiT-PsVLPs CS329503 SARS-CoV-2 S(Alpha) HiBIT-PsVLPs 5X CS329504 SARS-CoV-2 S(Beta) HiBiT-PsVLPs CS329505 SARS-CoV-2 S(Beta) HiBiT-PsVLPs 5X CS329506 SARS-CoV-2 S(Gamma) HiBiT-PsVLPs CS329507 SARS-CoV-2 S(Gamma) HiBIT-PsVLPs 5X CS329508 SARS-CoV-2 S(Epsilon) HiBiT-PsVLPs CS329511 SARS-CoV-2 S(Epsilon) HiBiT-PsVLPs 5X CS329512 SARS-CoV-2 S(Iota) HiBiT-PsVLPs CS329513 SARS-CoV-2 S(Iota) HiBIT-PsVLPs 5X CS329514 SARS-CoV-2 S(Kappa) HiBiT-PsVLPs CS329515 SARS-CoV-2 S(Kappa) HiBIT-PsVLPs 5X CS329516 VSV-G HiBiT-PsVLP Assay, Target Kit CS329531 VSV-G HiBiT-PsVLP Assay, Target Kit 5X CS329532 SARS-CoV-2 HEK293T(LgBiT) Target Cells CS329520 SARS-CoV-2 HEK293T(LgBiT) Target Cells 5X CS329521 SARS-CoV-2 HEK293T(LgBiT) Target Cells, Propagation Model CS329523 Return to Table of Contents PROMEGA CORPORATION • 2800 WOODS HOLLOW ROAD • MADISON, WI 53711 -5399 USA • TELEPHONE 608-274-4330 www.promega.com • © 2022 PROMEGA CORPORATION • ALL RIGHTS RESERVED • PRICES AND SPECIFICATIONS SUBJECT TO CHANGE WITHOUT PRIOR NOTICE • PRINTED IN USA 01/22 • 65014199 • #GE921 Cytokine and Growth Factor Bioassays Bioassay Part # IL-1 Bioassay IL-1 Bioassay CS200403 IL-1 Bioassay 5X CS200405 IL-1 Bioassay, Propagation Model4 CS200401 IL-2 Bioassays IL-2 Bioassay JA2201 IL-2 Bioassay 5X JA2205 IL-2 Bioassay, Propagation Model4 J2952 IL-2Rβγ Bioassay Kit CS2018K04 IL-2Rβγ Bioassay Kit 5X CS2018K06 IL-2Rβγ Bioassay, Propagation Model4 CS2018K02 IL-4 Bioassay IL-4 Bioassay Kit CS2018H06 IL-4 Bioassay Kit 5X CS2018H07 IL-4 Bioassay, Propagation Model4 CS2018H02 IL-6 Bioassay IL-6 Bioassay JA2501 IL-6 Bioassay 5X JA2505 IL-6 Bioassay, Propagation Model4 J2992 IL-7 Bioassay IL-7 Bioassay Kit CS2018J04 IL-7 Bioassay Kit 5X CS2018J06 IL-7 Bioassay, Propagation Model4 CS2018J02 IL-10 Bioassay IL-10 Bioassay Kit CS2018G04 IL-10 Bioassay Kit 5X CS2018G06 IL-10 Bioassay, Propagation Model4 CS2018G02 IL-12 Bioassay IL-12 Bioassay JA2601 IL-12 Bioassay 5X JA2605 IL-12 Bioassay, Propagation Model4 J3042 IL-13 Bioassay IL-13 Bioassay Kit CS2018H06 IL-13 Bioassay Kit 5X CS2018H07 IL-13 Bioassay, Propagation Model4 CS2018H02 IL-15 Bioassay IL-15 Bioassay JA2011 IL-15 Bioassay 5X JA2015 IL-15 Bioassay, Propagation Model4 J2962 IL-17 Bioassay IL-17 Bioassay Kit CS2018C06 IL-17 Bioassay Kit 5X CS2018C08 IL-17 Bioassay, Propagation Model4 CS2018C02 IL-21 Bioassay IL-21 Bioassay Kit CS2018M05 IL-21 Bioassay Kit, 5X CS2018M07 IL-21 Bioassay, Propagation Model4 CS2018M02 Return to Table of Contents PROMEGA CORPORATION • 2800 WOODS HOLLOW ROAD • MADISON, WI 53711 -5399 USA • TELEPHONE 608-274-4330 www.promega.com • © 2022 PROMEGA CORPORATION • ALL RIGHTS RESERVED • PRICES AND SPECIFICATIONS SUBJECT TO CHANGE WITHOUT PRIOR NOTICE • PRINTED IN USA 01/22 • 65014199 • #GE921 Cytokine and Growth Factor Bioassays (cont.) Bioassay Part # IL-22 Bioassay IL-22 Bioassay Kit CS2018L05 IL-22 Bioassay Kit 5X CS2018L07 IL-22 Bioassay, Propagation Model4 CS2018L02 IL-23 Bioassay IL-23 Bioassay JA2511 IL-23 Bioassay 5X JA2515 IL-23 Bioassay, Propagation Model4 J3002 VEGF Bioassays VEGF Bioassay GA2001 VEGF Bioassay 5X GA2005 VEGF Bioassay, Propagation Model4 GA1082 Recombinant Human VEGF J2371 VEGFR1 Bioassay CS2070A04 VEGFR1 Bioassay 5X CS2070A09 VEGFR1 Bioassay, Propagation Model4 CS2070A02 RANKL Bioassay RANKL Bioassay JA2701 RANKL Bioassay 5X JA2705 RANKL Bioassay, Propagation Model4 J3102 TGF-β Bioassay TGF-β Bioassay Kit CS2018F03 TGF-β Bioassay Kit 5X CS2018F06 TGF-β Bioassay, Propagation Model4 CS2018F02 BCMA Bioassay BCMA Bioassay Kit CS311108 BCMA Bioassay Kit 5X CS311110 BCMA Bioassay, Propagation Model4 CS311106 TPO Receptor (Nplate) Bioassay TPO Receptor (Nplate) Bioassay Cells CS2018E01 TPO Receptor (Nplate) Bioassay, Propagation Model4 CS2018E03 Other Reporter Cell Lines for Biologics Drug Development Cells & Cell lines Catalog or CS# TNFα Reporter Cells CS177503 TNFα Reporter Cell Line E8520 IFNα/IFN Reporter Cell Line CS190701 IFNα/IFNβ Bioassay Kit CS190704 IFNα/IFNβ Bioassay Kit 5X CS190706 IFN Reporter Cell Line Please Enquire EPO Reporter Cell Line22 CS204002 GM-CSF Reporter Cell Line22 EGF Reporter Cell Line CS181201 G-CSF Reporter Cell Line Please Enquire Return to Table of Contents PROMEGA CORPORATION • 2800 WOODS HOLLOW ROAD • MADISON, WI 53711 -5399 USA • TELEPHONE 608-274-4330 www.promega.com • © 2022 PROMEGA CORPORATION • ALL RIGHTS RESERVED • PRICES AND SPECIFICATIONS SUBJECT TO CHANGE WITHOUT PRIOR NOTICE • PRINTED IN USA 01/22 • 65014199 • #GE921 1Complete Kits contain thaw-and-use effector cells, target cells, control antibody, cell plating and assay reagents. 2Core Kits contain thaw-and-use effector cells, cell plating and assay reagents. 3Target Kits contain thaw-and-use target cells, control antibody. 4Propagation Model includes 2 vials of effector cells. 5ADCC Reporter Bioassays, F Variant are compatible with the Target Kits listed under “ADCC Reporter Bioassays”. 6Membrane Target Cells are also available in Propagation Model format – please enquire. 7The PD-1 and CTLA-4 Effector Cells included in the PD-1/PD-L1 and CTLA-4 Blockade Bioassays can be used as target cells in an ADCC bioassay. 8The receptor expressed in the Effector Cells is a chimeric receptor consisting of the extracellular domain of FcRIIb and the intracellular domain of FcRIIa. 9Kits contain the indicated thaw-and-use cell components, cell plating medium, assay reagents. 10aAPC (artificial antigen presenting cells) activate the TCR/CD3 complex on effector cells. 11Kits contain the indicated thaw-and-use cell components, TCR Activating Antigen, cell plating medium, assay reagents. 12The SIRPα/CD47 Blockade Bioassay is available in both Fc-dependent and Fc-independent formats. 13The ICOS and CD28 Bioassays are available in both blockade and agonist (below) formats. 14The ICOS and CD28 Bioassays are available in both agonist and blockade (above) formats. 15Includes a single vial of CD70 CHO-K1 Cells. 16Kits contain FcRIIb CHO-K1 Cells and cell plating medium. 17Kits contain FcRIIb aAPC/CHO-K1 Cells or aAPC/CHO-K1 Cells and cell plating medium. 18T Cell Activation bioassays are available with NFAT, IL-2, or NFkB promoter response elements. 19Cells available in thaw-and-use format. 20The DMF5 TCR recognizes MART-1 presented by class I MHC HLA-A*0201 (often used in cancer gene therapy). 21TLR effector cells express and respond to TLR1, TLR2, TLR4, TLR5, TLR6, TLR7, TLR8. 22The same cell line is responsive to both EPO and GM-CSF. 23Kit contains MHCII APC Cells, TCR Activating Antigen, Positive Control TCR Plasmid, cell plating medium. 24HiBiT Target Cells are also available in Propagation Model format. 25Cell Banks include 50 vials of effector cells. For more information on bioassays, visit: www.promega.com/bioassay For more information on custom assays, visit: www.promega.com/custom-bio